Thursday, July 24, 2008

Taking a pill reduces blood glucose of Diabetes 2 patients, muraglitazar Part 5




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Secondary Endpoint Results At week 104 of the study, mean changes in triglyceride levels frombaseline were -13 percent for PARGLUVA 1.5 mg (baseline 136 mg/dL), -22 percent for PARGLUVA 5 mg (baseline 156 mg/dL), -31% for PARGLUVA 10 mg (baseline 155 mg/dL), -39 percent for PARGLUVA 20 mg (baseline 138 mg/dL), and -12 percent for pioglitazone 15 mg (baseline 145 mg/dL). Mean increase in HDL cholesterol levels from baseline were 17 percent, 29 percent, 25 percent and 28 percent for PARGLUVA 1.5 mg (baseline 43 mg/dL), 5 mg (baseline 40 mg/dL), 10 mg (baseline 40 mg/dL), and 20 mg (baseline 42 mg/dL) respectively, and 18 percent for pioglitazone 15 mg (baseline 42 mg/dL) at week 104.



At week 104, mean changes in non-HDL cholesterol levels from baseline were -12 percent, -11 percent, -12 percent and -14 percent for PARGLUVA 1.5 mg (baseline 151 mg/dL), 5 mg (baseline 154 mg/dL), 10 mg (baseline 160 mg/dL), and 20 mg (baseline 158 mg/dL) respectively, and -9 percent for pioglitazone 15 mg (baseline 154 mg/dL). Mean changes in LDL cholesterol levels from baseline at week 104 were -10 percent, -6 percent, -5 percent and -7 percent for PARGLUVA 1.5 mg (baseline 118 mg/dL), 5 mg (baseline 116 mg/dL), 10 mg (baseline 123 mg/dL), and 20 mg (baseline 126 mg/dL), respectively, and -8 percent for pioglitazone 15 mg (baseline 123 mg/dL).



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